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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases expressionEXP 6480464CTDPhenobarbital results in decreased expression of CYP2E1 mRNA; Phenobarbital results in decreased expression of CYP2E1 proteinPMID:15596064 PMID:17381134 PMID:30842367 PMID:9118891
Cyp2e1increases activityEXP 6480464CTDPhenobarbital results in increased activity of CYP2E1 proteinPMID:15490126
Cyp2e1increases expressionEXP 6480464CTDPhenobarbital results in increased expression of CYP2E1 mRNA; Phenobarbital results in increased expression of CYP2E1 proteinPMID:18798224 PMID:23273579
Cyp2e1multiple interactionsEXP 6480464CTD[Phenobarbital co-treated with beta-Naphthoflavone] results in decreased expression of CYP2E1 protein; Choline deficiency promotes the reaction [Phenobarbital results in increased expression of CYP2E1 protein]PMID:18798224 PMID:30842367
Cyp2e1affects expressionISOCYP2E1 (Homo sapiens)6480464CTDPhenobarbital affects the expression of CYP2E1 proteinPMID:35881160
Cyp2e1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDPhenobarbital results in decreased expression of CYP2E1 mRNA; Phenobarbital results in decreased expression of CYP2E1 proteinPMID:30503582 PMID:35881160
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