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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:50867
Term: ciprofibrate
Definition: A cyclopropane that has formula C13H14Cl2O3.
Chemical ID: MESH:C019304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases expressionEXP 6480464CTDciprofibrate results in increased expression of CYP2E1 mRNAPMID:7587954
Cyp2e1multiple interactionsEXP 6480464CTD[Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Thiazoles co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]PMID:7587954
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