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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:4659
Term: disulfiram
Definition: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
Chemical ID: MESH:D004221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases activityEXP 6480464CTDDisulfiram results in decreased activity of CYP2E1 proteinPMID:9393675
Cyp2e1decreases expressionEXP 6480464CTDDisulfiram results in decreased expression of CYP2E1 mRNA; Disulfiram results in decreased expression of CYP2E1 proteinPMID:9393675
Cyp2e1multiple interactionsEXP 6480464CTDDisulfiram binds to and results in decreased activity of CYP2E1 proteinPMID:18754103
Cyp2e1decreases activityISOCYP2E1 (Homo sapiens)6480464CTDDisulfiram results in decreased activity of CYP2E1 proteinPMID:1664256 PMID:21915887 PMID:8637342
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of StyrenePMID:20470765
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane]PMID:10805064 PMID:20470765 PMID:21915887 PMID:23669205
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