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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases expression EXP 401794453RGD3-methylcholanthrene increases expression of mRNA, protein in rat heart 
Cyp2e1decreases activityEXP 6480464CTDMethylcholanthrene results in decreased activity of CYP2E1 proteinPMID:8734847
Cyp2e1decreases expressionEXP 6480464CTDMethylcholanthrene results in decreased expression of CYP2E1 mRNA; Methylcholanthrene results in decreased expression of CYP2E1 proteinPMID:3113478 PMID:7493548 PMID:8734847 PMID:9118891
Cyp2e1increases expressionEXP 6480464CTDMethylcholanthrene results in increased expression of CYP2E1 mRNA; Methylcholanthrene results in increased expression of CYP2E1 proteinPMID:10476907 PMID:19889059 PMID:23273579
Cyp2e1multiple interactionsEXP 6480464CTD[Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; [Methylcholanthrene results in decreased expression of CYP2E1 protein] which affects the metabolism of Benzene; [protocatechuic acid co-treated with Methylcholanthrene] results in decreased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Methylcholanthrene promotes the reaction [CYP2E1 protein results in increased oxidation of Toluene]PMID:15302093 PMID:1994898 PMID:8734847 PMID:9118891
Cyp2e1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDMethylcholanthrene results in decreased expression of CYP2E1 mRNAPMID:30503582
Cyp2e1decreases expressionISOCYP2E1 (Homo sapiens)6480464CTDMethylcholanthrene results in decreased expression of CYP2E1 mRNAPMID:28673560
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