GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2e1 | increases expression | EXP | | 401794453 | RGD | 3-methylcholanthrene increases expression of mRNA, protein in rat heart | | Cyp2e1 | decreases activity | EXP | | 6480464 | CTD | Methylcholanthrene results in decreased activity of CYP2E1 protein | PMID:8734847 | Cyp2e1 | decreases expression | EXP | | 6480464 | CTD | Methylcholanthrene results in decreased expression of CYP2E1 mRNA; Methylcholanthrene results in decreased expression of CYP2E1 protein | PMID:3113478 PMID:7493548 PMID:8734847 PMID:9118891 | Cyp2e1 | increases expression | EXP | | 6480464 | CTD | Methylcholanthrene results in increased expression of CYP2E1 mRNA; Methylcholanthrene results in increased expression of CYP2E1 protein | PMID:10476907 PMID:19889059 PMID:23273579 | Cyp2e1 | multiple interactions | EXP | | 6480464 | CTD | [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; [Methylcholanthrene results in decreased expression of CYP2E1 protein] which affects the metabolism of Benzene; [protocatechuic acid co-treated with Methylcholanthrene] results in decreased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Methylcholanthrene promotes the reaction [CYP2E1 protein results in increased oxidation of Toluene] | PMID:15302093 PMID:1994898 PMID:8734847 PMID:9118891 | Cyp2e1 | decreases expression | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Methylcholanthrene results in decreased expression of CYP2E1 mRNA | PMID:30503582 | Cyp2e1 | decreases expression | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | Methylcholanthrene results in decreased expression of CYP2E1 mRNA | PMID:28673560 | |
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