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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp2e1 Name: cytochrome P450, family 2, subfamily e, polypeptide 1

Acc ID: CHEBI:28097 Term: chlorobenzene Definition: The simplest member of the class of chlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine. CasRN: 108-90-7 Chemical ID: MESH:C031294

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1345007	6480464	CTD	dihydroxyethyldithiocarbamate inhibits the reaction [CYP2E1 protein results in increased metabolism of chlorobenzene]	PMID:9817075
increases oxidation	ISO	RGD:1345007	6480464	CTD	CYP2E1 protein results in increased oxidation of chlorobenzene	PMID:9817075
multiple interactions	EXP		6480464	CTD	[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene]	PMID:9817075
increases oxidation	EXP		6480464	CTD	CYP2E1 protein results in increased oxidation of chlorobenzene	PMID:9817075