Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1affects expressionEXP 6480464CTDCarbon Tetrachloride affects the expression of CYP2E1 mRNAPMID:17805973
Cyp2e1affects metabolic processingEXP 6480464CTDCYP2E1 protein affects the metabolism of Carbon TetrachloridePMID:15772367
Cyp2e1decreases activityEXP 6480464CTDCarbon Tetrachloride results in decreased activity of CYP2E1 proteinPMID:14706259 PMID:16288784 PMID:17410408
Cyp2e1decreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of CYP2E1 mRNA; Carbon Tetrachloride results in decreased expression of CYP2E1 proteinPMID:14706259 PMID:17606319 PMID:25450236 PMID:27623180 PMID:31150632 PMID:31168027
Cyp2e1increases activityEXP 6480464CTDCarbon Tetrachloride results in increased activity of CYP2E1 proteinPMID:17710613 PMID:25899501
Cyp2e1increases degradationEXP 6480464CTDCarbon Tetrachloride results in increased degradation of CYP2E1 proteinPMID:12679053
Cyp2e1increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of CYP2E1 mRNA; Carbon Tetrachloride results in increased expression of CYP2E1 proteinPMID:11903743 PMID:21224420 PMID:24582681 PMID:29129047
Cyp2e1increases metabolic processingEXP 6480464CTDCYP2E1 protein results in increased metabolism of Carbon TetrachloridePMID:7601153
Cyp2e1multiple interactionsEXP 6480464CTDacteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]; Alkaloids inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]; Alkaloids inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]; Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]; Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein; Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]; Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]; ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]; Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]; isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]; phenethyl isothiocyanate inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]; Propolis inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2E1 protein]; schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2E1 protein]; Silymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]PMID:11903743 PMID:14672760 PMID:17410408 PMID:1903091 PMID:21224420 PMID:24582681 PMID:25450236 PMID:25899501 PMID:29129047 PMID:31150632 PMID:7601153
Cyp2e1affects response to substanceISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein affects the susceptibility to Carbon TetrachloridePMID:15962327
Cyp2e1decreases activityISOCyp2e1 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased activity of CYP2E1 proteinPMID:17038628 PMID:19793341 PMID:29974145
Cyp2e1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of CYP2E1 mRNA; Carbon Tetrachloride results in decreased expression of CYP2E1 proteinPMID:12466116 PMID:12759355 PMID:15056808 PMID:15962327 PMID:16445600 PMID:18038451 PMID:19393728 PMID:19913046 PMID:25270620 PMID:25566828 PMID:25656916 PMID:26443840 PMID:29974145 PMID:29987408 PMID:31919559
Cyp2e1increases activityISOCyp2e1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased activity of CYP2E1 proteinPMID:25445725
Cyp2e1increases activityISOCYP2E1 (Homo sapiens)6480464CTDCarbon Tetrachloride results in increased activity of CYP2E1 proteinPMID:17710613
Cyp2e1increases expressionISOCyp2e1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of CYP2E1 mRNA; Carbon Tetrachloride results in increased expression of CYP2E1 proteinPMID:17610925 PMID:23279844 PMID:23994094 PMID:26218279 PMID:29964319
Cyp2e1increases metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased metabolism of Carbon TetrachloridePMID:15797236 PMID:18350910 PMID:8531136
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of CYP2E1 mRNA; Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 mRNA]; Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 protein]; Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein; Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein; CDKN1A protein affects the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of BNIP3 mRNA]; CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAR3 mRNA]; CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP1A2 mRNA]; CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL1RAP mRNA]; CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of PAH mRNA]; Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]; ginsan promotes the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]; HTS 466284 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; HTS 466284 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]; Lipids inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]; myricitrin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]; NUPR1 protein affects the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; NUPR1 protein affects the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]; Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]; rossicaside B inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]; Saponins inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]; Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]PMID:10355542 PMID:12759355 PMID:15962327 PMID:15983038 PMID:17084009 PMID:19793341 PMID:19913046 PMID:23279844 PMID:23994094 PMID:25445725 PMID:25566828 PMID:25656916 PMID:26218279 PMID:29964319 PMID:29974145 PMID:30517762
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTDCarbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]; Carbon Tetrachloride promotes the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; Carbon Tetrachloride results in increased degradation of and results in decreased activity of CYP2E1 protein; Cycloheximide promotes the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]; Dimethylnitrosamine inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; Dimethylnitrosamine inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]; Ethanol inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; Fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; Fomepizole inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]PMID:8531136 PMID:9143349
Go Back to source page   Continue to Ontology report