GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2e1 | multiple interactions | EXP | | 6480464 | CTD | 1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; [[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde; [Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite] | PMID:21842885 PMID:8211999 | Cyp2e1 | multiple interactions | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Glutathione inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein] | PMID:28803762 | Cyp2e1 | multiple interactions | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | [CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione; [CYP2E1 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene] | PMID:10573527 PMID:16872732 PMID:24246759 PMID:32198085 | | ||||||||||||||||||||||
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