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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[AQP4 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CYP2E1 mRNAPMID:20615459
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP2E1 mRNA; Lipopolysaccharides affects the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]PMID:16235733 PMID:22777745
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