GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2e1 | increases activity | EXP | | 6480464 | CTD | Acetone results in increased activity of CYP2E1 protein | PMID:12919724 PMID:20127315 PMID:3782137 PMID:8734847 PMID:9851676 | Cyp2e1 | increases expression | EXP | | 6480464 | CTD | Acetone results in increased expression of CYP2E1 mRNA; Acetone results in increased expression of CYP2E1 protein | PMID:11939710 PMID:12919724 PMID:15763544 PMID:1968335 PMID:2241968 PMID:3416296 PMID:3782137 PMID:8117100 PMID:8267643 PMID:8734847 | Cyp2e1 | multiple interactions | EXP | | 6480464 | CTD | 1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]; Acetone promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Acetone promotes the reaction [Toluene results in increased expression of CYP2E1 protein]; Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein] | PMID:7587954 PMID:8267643 PMID:8734847 PMID:8996725 PMID:9851676 | Cyp2e1 | increases expression | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Acetone results in increased expression of CYP2E1 mRNA; Acetone results in increased expression of CYP2E1 protein | PMID:18990727 PMID:22499231 | Cyp2e1 | increases metabolic processing | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | CYP2E1 protein results in increased metabolism of Acetone | PMID:15576447 | Cyp2e1 | multiple interactions | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | [Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene; [Acetone results in increased expression of CYP2E1 protein] which results in increased susceptibility to allyl cyanide; Acetone results in increased expression of and results in increased activity of CYP2E1 protein | PMID:18990727 PMID:8013281 PMID:8560479 | | ||||||||||||||||||||||
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