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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2469
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c11
Name: cytochrome P450, subfamily 2, polypeptide 11
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c11decreases activityEXP 6480464CTDKetoconazole results in decreased activity of CYP2C11 proteinPMID:15879494
Cyp2c11multiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]PMID:19858067
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