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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2469
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c11
Name: cytochrome P450, subfamily 2, polypeptide 11
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c11decreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of CYP2C mRNA; Diethylnitrosamine results in decreased expression of CYP2C11 mRNA; Diethylnitrosamine results in decreased expression of CYP2C11 proteinPMID:14965361 PMID:19041683 PMID:19638242 PMID:20360939 PMID:29698782
Cyp2c11multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 protein; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP2C mRNA; [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP2C mRNA; [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP2C mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2C mRNAPMID:16246485 PMID:17602206 PMID:18164116 PMID:18253720 PMID:18544905 PMID:28943392
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