GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2c11 | decreases expression | EXP | | 6480464 | CTD | Clofibric Acid results in decreased expression of CYP2C11 mRNA | PMID:15788368 | Cyp2c11 | multiple interactions | EXP | | 6480464 | CTD | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP2C mRNA; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; Clofibric Acid results in decreased expression of and results in decreased activity of CYP2C11 protein | PMID:15788368 PMID:17602206 | |
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