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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2462
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp24a1increases expressionEXP 6480464CTDLithocholic Acid results in increased expression of CYP24A1 mRNAPMID:17535892
Cyp24a1multiple interactionsEXP 6480464CTD[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; Vitamin D inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]PMID:17535892 PMID:21311750
Cyp24a1increases expressionISOCYP24A1 (Homo sapiens)6480464CTDLithocholic Acid results in increased expression of CYP24A1 mRNAPMID:19244278 PMID:20055894 PMID:21917910 PMID:22466564
Cyp24a1increases expressionISOCyp24a1 (Mus musculus)6480464CTDLithocholic Acid analog results in increased expression of CYP24A1 mRNA; Lithocholic Acid results in increased expression of CYP24A1 mRNAPMID:15489543 PMID:18180267
Cyp24a1multiple interactionsISOCYP24A1 (Homo sapiens)6480464CTD[Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; Benzo(a)pyrene promotes the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; HR protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; Lithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]; Lithocholic Acid promotes the reaction [VDR protein binds to CYP24A1 promoter]PMID:15489543 PMID:18180267 PMID:19244278 PMID:20055894 PMID:21917910 PMID:22466564
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