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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionEXP 6480464CTDandrographolide results in increased expression of CYP1A2 mRNAPMID:19041297
Cyp1a2multiple interactionsEXP 6480464CTDandrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]PMID:20096675
Cyp1a2decreases expressionISOCYP1A2 (Homo sapiens)6480464CTDandrographolide results in decreased expression of CYP1A2 mRNAPMID:19041297
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDandrographolide results in increased expression of CYP1A2 mRNAPMID:17825862
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A2 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 mRNAPMID:17825862 PMID:19737545
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