GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that has formula C22H29FO5.
CasRN: 50-02-2
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7357116480464CTD[Dexamethasone co-treated with Mifepristone] results in increased activity of CYP1A2 protein

[Dexamethasone co-treated with Mifepristone] promotes the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]

Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]

Dexamethasone inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]

Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]

Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]]

Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]]

PMID:19022236
decreases expressionISORGD:7357116480464CTDDexamethasone results in decreased expression of CYP1A2 protein

PMID:19022236
decreases activityISORGD:7357116480464CTDDexamethasone results in decreased activity of CYP1A2 protein

PMID:19022236
affects expressionEXP 6480464CTDDexamethasone affects the expression of CYP1A2 mRNA

PMID:15102944
multiple interactionsEXP 6480464CTDDexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]

Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]]

PMID:17690134
increases expressionEXP 6480464CTDDexamethasone results in increased expression of CYP1A2 mRNA

PMID:15607757
decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of CYP1A2 mRNA

PMID:20607812
PMID:20832446
PMID:11328961
decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of CYP1A2 mRNA

PMID:20832446
PMID:11328961
PMID:20607812
decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of CYP1A2 mRNA

PMID:20832446
PMID:20607812
PMID:11328961
decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of CYP1A2 mRNA

PMID:11328961
PMID:20607812
PMID:20832446
Go Back to source page   Continue to Ontology report