GENE - CHEMICAL INTERACTIONS REPORT
RGD ID:
2459
Species:
Rattus norvegicus
RGD Object:
Gene
Symbol:
Cyp1a2
Name:
cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID:
CHEBI:41879
Term:
dexamethasone
Definition:
A fluorinated steroid that has formula C22H29FO5.
CasRN:
50-02-2
Chemical ID:
MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
multiple interactions ISO RGD:735711 6480464 CTD [Dexamethasone co-treated with Mifepristone] results in increased activity of CYP1A2 protein [Dexamethasone co-treated with Mifepristone] promotes the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein] Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA] Dexamethasone inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein] Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]] Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]] PMID:19022236 decreases expression ISO RGD:735711 6480464 CTD Dexamethasone results in decreased expression of CYP1A2 protein PMID:19022236 decreases activity ISO RGD:735711 6480464 CTD Dexamethasone results in decreased activity of CYP1A2 protein PMID:19022236 affects expression EXP 6480464 CTD Dexamethasone affects the expression of CYP1A2 mRNA PMID:15102944 multiple interactions EXP 6480464 CTD Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]] PMID:17690134 increases expression EXP 6480464 CTD Dexamethasone results in increased expression of CYP1A2 mRNA PMID:15607757 decreases expression EXP 6480464 CTD Dexamethasone results in decreased expression of CYP1A2 mRNA PMID:20607812 PMID:20832446 PMID:11328961 decreases expression EXP 6480464 CTD Dexamethasone results in decreased expression of CYP1A2 mRNA PMID:20832446 PMID:11328961 PMID:20607812 decreases expression EXP 6480464 CTD Dexamethasone results in decreased expression of CYP1A2 mRNA PMID:20832446 PMID:20607812 PMID:11328961 decreases expression EXP 6480464 CTD Dexamethasone results in decreased expression of CYP1A2 mRNA PMID:11328961 PMID:20607812 PMID:20832446