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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:38102
Term: triazines
Definition: Compounds based on a triazine skeleton.
Chemical ID: MESH:D014227
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of TriazinesPMID:9305587
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]; furafylline inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]; Gestodene inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]; Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]PMID:9305587
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