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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:37187
Term: lead nitrate
Definition: A lead coordination entity that has formula N2O6Pb.
Chemical ID: MESH:C017461
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2multiple interactionsEXP 6480464CTDlead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; lead nitrate results in decreased expression of and results in decreased activity of CYP1A2 proteinPMID:8902619
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDlead nitrate results in decreased activity of CYP1A2 proteinPMID:11162773
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