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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34591
Term: bromodichloromethane
Definition: A halomethane that is dichloromethane in which oneof the hydrogens has been replaced by a bromine atom. It occurs as a contaminant in drinking water.
Chemical ID: MESH:C025191
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects metabolic processingEXP 6480464CTDCYP1A2 protein affects the metabolism of bromodichloromethanePMID:12062927
Cyp1a2decreases expressionEXP 6480464CTDbromodichloromethane results in decreased expression of CYP1A2 proteinPMID:11295256
Cyp1a2increases expressionEXP 6480464CTDbromodichloromethane results in increased expression of CYP1A2 proteinPMID:11295256
Cyp1a2increases metabolic processingEXP 6480464CTDCYP1A2 protein results in increased metabolism of bromodichloromethanePMID:11295256 PMID:12076521
Cyp1a2multiple interactionsEXP 6480464CTDisosafrole inhibits the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane]; Tetrachlorodibenzodioxin promotes the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane]PMID:12062927
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of bromodichloromethanePMID:12076521
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