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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP1A2 proteinPMID:15659567
Cyp1a2increases activityEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP1A2 proteinPMID:16628245
Cyp1a2increases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A2 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A2 proteinPMID:16049271 PMID:19692669 PMID:20959002 PMID:25530946 PMID:34256052
Cyp1a2multiple interactionsEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [CYP1A2 protein results in decreased methylation of 7-methoxyresorufin]; [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased activity of CYP1A2 protein; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl] results in increased activity of CYP1A2 protein; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased activity of CYP1A2 protein; [Tetrachlorodibenzodioxin co-treated with 2,3,4,7,8-pentachlorodibenzofuran co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased activity of CYP1A2 protein; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A2 mRNA]PMID:12635099 PMID:16835634 PMID:17160104 PMID:17342195 PMID:17342196 PMID:34256052
Cyp1a2affects expressionISOCyp1a2 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl affects the expression of CYP1A2 mRNAPMID:31563530
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP1A2 proteinPMID:15659567
Cyp1a2decreases response to substanceISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 results in decreased susceptibility to 3,4,5,3',4'-pentachlorobiphenylPMID:21571617
Cyp1a2increases activityISOCyp1a2 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP1A2 proteinPMID:10986007
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A2 mRNAPMID:20702594 PMID:21335049 PMID:23674508 PMID:26770886 PMID:28163111 PMID:28973532 PMID:30312631
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl analog results in increased expression of CYP1A2 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A2 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A2 proteinPMID:16049271 PMID:19692669 PMID:25068733 PMID:36372259
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYP1A2 mRNA; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]; [aroclor 1260 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of CYP1A2 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of CYP1A2 mRNA; [MT1 protein affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which affects the expression of CYP1A2 mRNA; [MT2 protein affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which affects the expression of CYP1A2 mRNAPMID:20961953 PMID:26770886 PMID:28163111 PMID:28973532 PMID:30312631
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