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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:28851
Term: phenanthrene
Definition: A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'
Chemical ID: MESH:C031181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases activityISOCyp1a2 (Mus musculus)6480464CTDphenanthrene results in increased activity of CYP1A2 proteinPMID:8001243
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDphenanthrene results in increased expression of CYP1A2 mRNA; phenanthrene results in increased expression of CYP1A2 proteinPMID:31181217
Cyp1a2increases oxidationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased oxidation of phenanthrenePMID:27137136
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA; CYP1A2 protein results in increased metabolism of and results in increased activity of phenanthrenePMID:19766613 PMID:7750161
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol; CYP1A2 protein results in increased metabolism of and results in increased activity of phenanthrenePMID:19766613 PMID:27137136
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