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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:17356
Term: 2-acetamidofluorene
Definition: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Chemical ID: MESH:D015073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases expressionEXP 6480464CTD2-Acetylaminofluorene analog results in decreased expression of CYP1A2 protein; 2-Acetylaminofluorene results in decreased expression of CYP1A2 proteinPMID:15916741
Cyp1a2increases expressionEXP 6480464CTD2-Acetylaminofluorene results in increased expression of CYP1A2 proteinPMID:28245158
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of 2-AcetylaminofluorenePMID:2655891
Cyp1a2increases activityISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased activity of 2-AcetylaminofluorenePMID:15450435
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTD2-Acetylaminofluorene results in increased expression of CYP1A2 mRNAPMID:16381673
Cyp1a2increases hydrolysisISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 results in increased hydrolysis of 2-AcetylaminofluorenePMID:2334931
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTDNR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]PMID:16381673
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