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GENE - TERM ANNOTATION REPORT

RGD ID: 2457
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: DOID:11612
Term: polycystic ovary syndrome
Definition: An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight. (DO)
Definition Source(s): http://ghr.nlm.nih.gov/glossary=polycysticovarysyndrome "DO" "DO", https://en.wikipedia.org/wiki/Polycystic_ovary_syndrome "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/28791858 "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/20591140 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1 IEP 7257717RGDmRNA, protein:decreased expresssion:ovary 
Cyp19a1 IMP 7257726RGD  
Cyp19a1susceptibilityISOCYP19A1 (Homo sapiens)7257710RGDDNA:missense mutation:cds:p.A264C (rs700519) (human) 
Cyp19a1 ISOCYP19A1 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:8265607 PMID:9177373 PMID:21262361 PMID:22381227
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