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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2398
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cpt2
Name: carnitine palmitoyltransferase 2
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cpt2increases expressionEXP 6480464CTDBezafibrate results in increased expression of CPT2 mRNAPMID:16707586
Cpt2increases activityISOCPT2 (Homo sapiens)6480464CTDBezafibrate results in increased activity of CPT2 proteinPMID:21816645
Cpt2increases expressionISOCPT2 (Homo sapiens)6480464CTDBezafibrate results in increased expression of CPT2 mRNAPMID:21816645
Cpt2multiple interactionsISOCPT2 (Homo sapiens)6480464CTD[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate; [Oleic Acid co-treated with Bezafibrate] results in increased expression of CPT2 mRNA; Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate]PMID:21816645 PMID:24534255
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