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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2398
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cpt2
Name: carnitine palmitoyltransferase 2
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cpt2increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of CPT2 mRNA; perfluorooctanoic acid results in increased expression of CPT2 proteinPMID:16221955 PMID:19162173 PMID:28511854 PMID:34958885
Cpt2affects expressionISOCpt2 (Mus musculus)6480464CTDperfluorooctanoic acid affects the expression of CPT2 mRNAPMID:19429403
Cpt2increases expressionISOCpt2 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of CPT2 mRNAPMID:18467677 PMID:20936131 PMID:23626681 PMID:28558994 PMID:30508572
Cpt2increases expressionISOCPT2 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of CPT2 mRNAPMID:23978341 PMID:25868421 PMID:32588087 PMID:37302725
Cpt2multiple interactionsISOCpt2 (Mus musculus)6480464CTDDietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of CPT2 mRNA]; PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of CPT2 mRNA]PMID:18467677 PMID:20936131 PMID:23626681
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