GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Comt | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of COMT mRNA | PMID:32145629 | Comt | increases activity | EXP | | 6480464 | CTD | Estradiol results in increased activity of COMT protein | PMID:20600213 | Comt | multiple interactions | EXP | | 6480464 | CTD | Quercetin inhibits the reaction [Estradiol results in increased activity of COMT protein] | PMID:20600213 | Comt | decreases abundance | ISO | COMT (Homo sapiens) | 6480464 | CTD | COMT protein polymorphism results in decreased abundance of Estradiol analog | PMID:15288375 | Comt | decreases activity | ISO | COMT (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased activity of COMT protein | PMID:18192686 PMID:18497090 | Comt | decreases expression | ISO | COMT (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of COMT mRNA; Estradiol results in decreased expression of COMT protein | PMID:18497090 PMID:24040167 PMID:30684530 PMID:31646340 PMID:35747940 | Comt | increases methylation | ISO | COMT (Homo sapiens) | 6480464 | CTD | COMT protein results in increased methylation of Estradiol metabolite; Estradiol results in increased methylation of COMT promoter | PMID:22285433 PMID:30684530 | Comt | multiple interactions | ISO | COMT (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of COMT protein; [Estradiol results in increased methylation of COMT promoter] which results in decreased expression of COMT mRNA; Decitabine inhibits the reaction [Estradiol results in decreased expression of COMT mRNA]; Decitabine inhibits the reaction [Estradiol results in increased methylation of COMT promoter]; Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Estradiol inhibits the reaction [EP300 protein binds to COMT promoter]; Estradiol promotes the reaction [DNMT3B protein binds to COMT promoter]; Estradiol promotes the reaction [HDAC1 protein binds to COMT promoter]; Estradiol promotes the reaction [MBD2 protein binds to COMT promoter]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of COMT mRNA]; sulforaphane inhibits the reaction [Estradiol promotes the reaction [DNMT3B protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Estradiol promotes the reaction [HDAC1 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Estradiol promotes the reaction [MBD2 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Estradiol results in decreased expression of COMT mRNA]; sulforaphane inhibits the reaction [Estradiol results in increased methylation of COMT promoter]; trichostatin A inhibits the reaction [Estradiol results in decreased expression of COMT mRNA] | PMID:18192686 PMID:18497090 PMID:30684530 PMID:35747940 | | ||||||||||||||||||||||
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