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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col2a1
Name: collagen type II alpha 1 chain
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col2a1decreases expressionEXP 6480464CTDTretinoin results in decreased expression of COL2A1 mRNA; Tretinoin results in decreased expression of COL2A1 proteinPMID:23810783
Col2a1decreases expressionISOCol2a1 (Mus musculus)6480464CTDTretinoin results in decreased expression of COL2A1 mRNA; Tretinoin results in decreased expression of COL2A1 proteinPMID:22498432
Col2a1increases expressionISOCOL2A1 (Homo sapiens)6480464CTDTretinoin results in increased expression of COL2A1 mRNAPMID:21934132
Col2a1multiple interactionsISOCol2a1 (Mus musculus)6480464CTD[bisphenol F co-treated with Tretinoin] results in decreased expression of COL2A1 mRNA; [bisphenol S co-treated with Tretinoin] results in decreased expression of COL2A1 mRNAPMID:30951980
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