GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcc2 | increases activity | EXP | | 6480464 | CTD | Probenecid results in increased activity of ABCC2 protein | PMID:15904671 | Abcc2 | increases export | EXP | | 6480464 | CTD | ABCC2 protein results in increased export of Probenecid | PMID:12608533 | Abcc2 | multiple interactions | EXP | | 6480464 | CTD | [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of resveratrol metabolite; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium | PMID:19853032 PMID:20089784 | Abcc2 | increases activity | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | Probenecid results in increased activity of ABCC2 protein | PMID:15849751 PMID:17478601 | Abcc2 | multiple interactions | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Probenecid promotes the reaction [ABCC2 protein affects the transport of docetaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Etoposide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Paclitaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Vinblastine]; Probenecid promotes the reaction [ABCC2 protein results in decreased susceptibility to Paclitaxel] | PMID:11477083 PMID:12704183 PMID:15849751 PMID:27450509 | |
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