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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366 Species: Rattus norvegicus RGD Object: Gene Symbol: Abcc2 Name: ATP-binding cassette, subfamily C (CFTR/MRP), member 2

Acc ID: CHEBI:4903 Term: 17alpha-ethynylestradiol Definition: A 17-hydroxy steroid that has formula C20H24O2. CasRN: 57-63-6 Chemical ID: MESH:D004997

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases uptake	ISO	RGD:619569	6480464	CTD	ABCC2 protein results in increased uptake of Ethinyl Estradiol metabolite	PMID:14722317
multiple interactions	ISO	RGD:619569	6480464	CTD	Ethinyl Estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]	PMID:14722317
affects localization	EXP		6480464	CTD	Ethinyl Estradiol affects the localization of ABCC2 protein	PMID:17681005
multiple interactions	EXP		6480464	CTD	[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein	PMID:17686906
multiple interactions	EXP		6480464	CTD	[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC2 mRNA	PMID:16105132
decreases expression	EXP		6480464	CTD	Ethinyl Estradiol results in decreased expression of ABCC2 protein	PMID:9462655 PMID:16554369 PMID:17686906
multiple interactions	EXP		6480464	CTD	Ethinyl Estradiol results in decreased expression of and results in decreased localization of and results in decreased activity of ABCC2 protein Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased activity of ABCC2 protein]	PMID:15843489
decreases expression	EXP		6480464	CTD	Ethinyl Estradiol results in decreased expression of ABCC2 protein	PMID:16554369 PMID:9462655 PMID:17686906
decreases expression	EXP		6480464	CTD	Ethinyl Estradiol results in decreased expression of ABCC2 protein	PMID:16554369 PMID:17686906 PMID:9462655
decreases expression	EXP		6480464	CTD	Ethinyl Estradiol results in decreased expression of ABCC2 protein	PMID:17686906 PMID:9462655 PMID:16554369
decreases expression	EXP		6480464	CTD	Ethinyl Estradiol results in decreased expression of ABCC2 protein	PMID:16554369 PMID:17686906 PMID:23146761 PMID:9462655