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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects exportEXP 6480464CTDABCC2 protein affects the export of Acetaminophen analogPMID:15860656
Abcc2affects response to substanceEXP 6480464CTDABCC2 protein affects the susceptibility to AcetaminophenPMID:16271353
Abcc2increases exportEXP 6480464CTDABCC2 protein results in increased export of AcetaminophenPMID:16271353
Abcc2increases expressionEXP 6480464CTDAcetaminophen results in increased expression of ABCC2 mRNA; Acetaminophen results in increased expression of ABCC2 proteinPMID:15276087 PMID:17126469
Abcc2multiple interactionsEXP 6480464CTD[Acetaminophen co-treated with Uranium analog] results in increased expression of ABCC2 mRNA; ABCC2 protein affects the reaction [Acetaminophen results in increased activity of SORD protein]; Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of Glutathione Disulfide]; Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; Uranium analog promotes the reaction [Acetaminophen results in increased expression of ABCC2 mRNA]PMID:15276087 PMID:16271353 PMID:17126469
Abcc2affects expressionISOAbcc2 (Mus musculus)6480464CTDAcetaminophen affects the expression of ABCC2 mRNAPMID:17562736
Abcc2decreases expressionISOABCC2 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of ABCC2 mRNAPMID:21420995 PMID:26690555 PMID:29067470
Abcc2increases expressionISOAbcc2 (Mus musculus)6480464CTDAcetaminophen results in increased expression of ABCC2 mRNA; Acetaminophen results in increased expression of ABCC2 proteinPMID:15496496 PMID:16177239
Abcc2multiple interactionsISOAbcc2 (Mus musculus)6480464CTD[Acetaminophen co-treated with Propylene Glycol] results in increased expression of ABCC2 mRNA; [Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein]PMID:17934960 PMID:35243748
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTD[Adenosine Triphosphate affects the activity of ABCC2 protein] which results in increased transport of Acetaminophen metabolite; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of ABCC2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 proteinPMID:32472168 PMID:33819548 PMID:35243748
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