GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcc2 | affects export | EXP | | 6480464 | CTD | ABCC2 protein affects the export of Acetaminophen analog | PMID:15860656 | Abcc2 | affects response to substance | EXP | | 6480464 | CTD | ABCC2 protein affects the susceptibility to Acetaminophen | PMID:16271353 | Abcc2 | increases export | EXP | | 6480464 | CTD | ABCC2 protein results in increased export of Acetaminophen | PMID:16271353 | Abcc2 | increases expression | EXP | | 6480464 | CTD | Acetaminophen results in increased expression of ABCC2 mRNA; Acetaminophen results in increased expression of ABCC2 protein | PMID:15276087 PMID:17126469 | Abcc2 | multiple interactions | EXP | | 6480464 | CTD | [Acetaminophen co-treated with Uranium analog] results in increased expression of ABCC2 mRNA; ABCC2 protein affects the reaction [Acetaminophen results in increased activity of SORD protein]; Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of Glutathione Disulfide]; Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; Uranium analog promotes the reaction [Acetaminophen results in increased expression of ABCC2 mRNA] | PMID:15276087 PMID:16271353 PMID:17126469 | Abcc2 | affects expression | ISO | Abcc2 (Mus musculus) | 6480464 | CTD | Acetaminophen affects the expression of ABCC2 mRNA | PMID:17562736 | Abcc2 | decreases expression | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | Acetaminophen results in decreased expression of ABCC2 mRNA | PMID:21420995 PMID:26690555 PMID:29067470 | Abcc2 | increases expression | ISO | Abcc2 (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased expression of ABCC2 mRNA; Acetaminophen results in increased expression of ABCC2 protein | PMID:15496496 PMID:16177239 | Abcc2 | multiple interactions | ISO | Abcc2 (Mus musculus) | 6480464 | CTD | [Acetaminophen co-treated with Propylene Glycol] results in increased expression of ABCC2 mRNA; [Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein] | PMID:17934960 PMID:35243748 | Abcc2 | multiple interactions | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | [Adenosine Triphosphate affects the activity of ABCC2 protein] which results in increased transport of Acetaminophen metabolite; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of ABCC2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein | PMID:32472168 PMID:33819548 PMID:35243748 | |
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