Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects expressionEXP 6480464CTDMercuric Chloride affects the expression of ABCC2 mRNAPMID:28536007
Abcc2affects response to substanceEXP 6480464CTDABCC2 gene mutant form affects the susceptibility to Mercuric ChloridePMID:25145654
Abcc2increases expressionEXP 6480464CTDMercuric Chloride results in increased expression of ABCC2 mRNAPMID:32599119
Abcc2multiple interactionsEXP 6480464CTDABCC2 protein affects the reaction [Succimer binds to and results in increased secretion of [Mercuric Chloride binds to Cysteine]]; ABCC2 protein affects the reaction [Unithiol binds to and results in increased secretion of [Mercuric Chloride binds to Cysteine]]; ABCC2 protein binds to and results in increased secretion of [Succimer binds to [Mercuric Chloride binds to Cysteine]]; ABCC2 protein binds to and results in increased secretion of [Unithiol binds to [Mercuric Chloride binds to Cysteine]]PMID:18511429
Abcc2affects response to substanceISOAbcc2 (Mus musculus)6480464CTDABCC2 gene mutant form affects the susceptibility to Mercuric ChloridePMID:25145654
Abcc2decreases response to substanceISOABCC2 (Homo sapiens)6480464CTDABCC2 protein results in decreased susceptibility to Mercuric ChloridePMID:21783896
Abcc2increases expressionISOAbcc2 (Mus musculus)6480464CTDMercuric Chloride results in increased expression of ABCC2 mRNAPMID:27720909
Abcc2multiple interactionsISOAbcc2 (Mus musculus)6480464CTDABCC2 gene mutant form promotes the reaction [Mercuric Chloride results in increased expression of GCLM mRNA]PMID:24039982
Go Back to source page   Continue to Ontology report