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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of ABCC2 mRNAPMID:28341572
Abcc2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ABCC2 proteinPMID:21048045
Abcc2multiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of and results in increased activity of ABCC2 proteinPMID:22472606
Abcc2affects expressionISOAbcc2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ABCC2 mRNAPMID:21570461
Abcc2increases expressionISOAbcc2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ABCC2 mRNAPMID:15833929 PMID:21095216 PMID:22496397 PMID:29452137
Abcc2multiple interactionsISOAbcc2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ABCC2 mRNA; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ABCC2 mRNA]; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of ABCC2 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ABCC2 mRNA]PMID:15833929 PMID:17627975 PMID:22496397 PMID:29452137
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