A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:
MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
formononetin promotes the reaction [Cisplatin results in increased expression of ABCC2 mRNA]; JBP 485 promotes the reaction [Cisplatin results in increased expression of ABCC2 mRNA]; JBP 485 promotes the reaction [Cisplatin results in increased expression of ABCC2 protein]; Lovastatin promotes the reaction [Cisplatin results in decreased expression of ABCC2 mRNA]
[Luteolin co-treated with Cisplatin] results in increased expression of ABCC2 protein; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein]; Luteolin inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein]; NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of ABCC2 mRNA]; NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of ABCC2 protein]
[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCC2 mRNA; [Cisplatin co-treated with jinfukang] results in increased expression of ABCC2 mRNA; [Omeprazole results in increased susceptibility to Cisplatin] which results in decreased expression of ABCC2 protein; [Proadifen co-treated with Cisplatin] results in increased expression of ABCC2 protein; [PTGS2 protein results in increased expression of ABCC2 protein] which results in increased susceptibility to Cisplatin; ABCC2 protein inhibits the reaction [ABCC2 gene mutant form results in increased susceptibility to Cisplatin]; kang-lai-te inhibits the reaction [Cisplatin results in increased expression of ABCC2 mRNA]; kang-lai-te inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein]
