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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2350
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrnb2
Name: cholinergic receptor nicotinic beta 2 subunit
Acc ID: CHEBI:16684
Term: atropine
Definition: A racemate composed of equimolar concentrations of (S)- and (R)-atropine . It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae.
Chemical ID: MESH:D001285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrnb2multiple interactionsEXP 6480464CTDAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]PMID:21791372
Chrnb2affects bindingISOCHRNB2 (Homo sapiens)6480464CTDAtropine binds to [CHRNA4 protein binds to CHRNB2 protein]PMID:15733544
Chrnb2multiple interactionsISOCHRNB2 (Homo sapiens)6480464CTDAtropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]PMID:15733544
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