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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2346
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna4
Name: cholinergic receptor nicotinic alpha 4 subunit
Acc ID: CHEBI:34705
Term: dihydro-beta-erythroidine
Definition: An organic heterotetracyclic compound resulting from the partial hydrogenation of the 1,3-diene moiety of beta-erythroidine to give the corresponding 2-ene.
Chemical ID: MESH:D004079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna4multiple interactionsEXP 2303194RGDdihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrna4 protein] 
Chrna4multiple interactionsEXP 2303195RGDdihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina 
Chrna4affects bindingEXP 6480464CTD[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-ErythroidinePMID:9687574
Chrna4multiple interactionsEXP 6480464CTD[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]PMID:10945867 PMID:11600638 PMID:16915382 PMID:18385335 PMID:19047205 PMID:28555334
Chrna4multiple interactionsISOChrna4 (Mus musculus)6480464CTDDihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]PMID:16569710 PMID:20100906
Chrna4multiple interactionsISOCHRNA4 (Homo sapiens)6480464CTDCarbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]PMID:12604691 PMID:14645658
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