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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2343
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrm3
Name: cholinergic receptor, muscarinic 3
Acc ID: CHEBI:16684
Term: atropine
Definition: A racemate composed of equimolar concentrations of (S)- and (R)-atropine . It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae.
Chemical ID: MESH:D001285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm3decreases activityISOCHRM3 (Homo sapiens)6480464CTDAtropine results in decreased activity of CHRM3 proteinPMID:31830555
Chrm3multiple interactionsISOCHRM3 (Homo sapiens)6480464CTDAtropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]PMID:15140916 PMID:20708676
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