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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2343
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrm3
Name: cholinergic receptor, muscarinic 3
Acc ID: CHEBI:107736
Term: metoclopramide
Definition: A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Chemical ID: MESH:D008787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm3affects bindingEXP 6480464CTDMetoclopramide binds to CHRM3 proteinPMID:15105209
Chrm3multiple interactionsEXP 6480464CTD[Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol; Metoclopramide inhibits the reaction [4-diphenylacetoxy-N-methylpiperidine methobromide binds to CHRM3 protein]PMID:15105209
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