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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cftr
Name: CF transmembrane conductance regulator
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftraffects localizationISOCFTR (Homo sapiens)6480464CTDApigenin affects the localization of CFTR protein mutant formPMID:15191910
Cftrincreases activityISOCFTR (Homo sapiens)6480464CTDApigenin results in increased activity of CFTR protein; Apigenin results in increased activity of CFTR protein mutant formPMID:15191910 PMID:15277574
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