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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpe
Name: CCAAT/enhancer binding protein epsilon
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpeincreases expressionISOCebpe (Mus musculus)6480464CTDTretinoin results in increased expression of CEBPE mRNAPMID:36189433
Cebpeincreases expressionISOCEBPE (Homo sapiens)6480464CTDTretinoin results in increased expression of CEBPE mRNA; Tretinoin results in increased expression of CEBPE proteinPMID:12130515 PMID:15770638 PMID:16054129 PMID:16184197 PMID:16647867 PMID:16766008 PMID:20945414 PMID:29743969 PMID:29945211 PMID:33167477
Cebpemultiple interactionsISOCebpe (Mus musculus)6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of CEBPE mRNAPMID:36189433
Cebpemultiple interactionsISOCEBPE (Homo sapiens)6480464CTD3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]; [Auranofin co-treated with Tretinoin] results in increased expression of CEBPE protein; [Tretinoin co-treated with Arsenic Trioxide co-treated with Butyrates] results in increased expression of CEBPE mRNA; [Tretinoin co-treated with Arsenic Trioxide co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA; [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of CEBPE mRNA; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA; Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]]; Acetylcysteine inhibits the reaction [cypermethrin inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]]; Arsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of CEBPE protein]; cypermethrin inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]; MIR106A mRNA inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]; STAT1 protein affects the reaction [Tretinoin results in increased expression of CEBPE protein]; Tretinoin inhibits the reaction [CAMK2G protein binds to CEBPE promoter]; Tretinoin promotes the reaction [caffeic acid phenethyl ester results in increased expression of CEBPE protein]PMID:12130515 PMID:15159275 PMID:16184197 PMID:16766008 PMID:16918696 PMID:17431504 PMID:20945414 PMID:29743969 PMID:29945211
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