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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2327
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpb
Name: CCAAT/enhancer binding protein beta
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpbincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CEBPB mRNA; Lipopolysaccharides results in increased expression of CEBPB proteinPMID:11779202 PMID:21068073 PMID:21192080
Cebpbincreases activityISOCebpb (Mus musculus)6480464CTDLipopolysaccharides results in increased activity of CEBPB proteinPMID:14670622 PMID:15832817
Cebpbincreases expressionISOCebpb (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CEBPB mRNA; Lipopolysaccharides results in increased expression of CEBPB proteinPMID:17316017 PMID:34952004
Cebpbincreases expressionISOCEBPB (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CEBPB mRNAPMID:21911040
Cebpbmultiple interactionsISOCebpb (Mus musculus)6480464CTD3,3',4,5'-tetrahydroxystilbene promotes the reaction [Lipopolysaccharides results in increased expression of CEBPB protein]; [[PTPN6 protein results in increased phosphorylation of MAPK1 protein] which results in increased activity of CEBPB protein] promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; [[PTPN6 protein results in increased phosphorylation of MAPK3 protein] which results in increased activity of CEBPB protein] promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; arachidin-1 promotes the reaction [Lipopolysaccharides results in increased expression of CEBPB protein]; Genistein inhibits the reaction [Lipopolysaccharides results in increased activity of CEBPB protein]; genistin inhibits the reaction [Lipopolysaccharides results in increased activity of CEBPB protein]; resveratrol promotes the reaction [Lipopolysaccharides results in increased expression of CEBPB protein]PMID:15832817 PMID:17316017 PMID:21422245
Cebpbmultiple interactionsISOCEBPB (Homo sapiens)6480464CTDtrichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of CEBPB mRNA]PMID:21911040
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