GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdk1 | decreases expression | ISO | CDK1 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in decreased expression of CDK1 mRNA | PMID:18058816 | Cdk1 | increases activity | ISO | CDK1 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased activity of CDK1 protein | PMID:10516758 | Cdk1 | increases phosphorylation | ISO | CDK1 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased phosphorylation of CDK1 protein | PMID:34648812 | Cdk1 | multiple interactions | ISO | CDK1 (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide co-treated with Paclitaxel] results in increased activity of CDK1 protein; [Arsenic Trioxide co-treated with Paclitaxel] results in increased expression of CDK1 protein modified form; [FV-429 compound co-treated with Oxygen deficiency co-treated with Paclitaxel] affects the phosphorylation of CDK1 protein; [FV-429 compound co-treated with Paclitaxel] results in increased phosphorylation of CDK1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of CDK1 mRNA; [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein; bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein]; HIF1A protein affects the reaction [Paclitaxel promotes the reaction [Oxygen deficiency results in decreased phosphorylation of CDK1 protein]]; Paclitaxel promotes the reaction [Oxygen deficiency results in decreased phosphorylation of CDK1 protein] | PMID:10516758 PMID:18516295 PMID:19781537 PMID:29309887 PMID:34648812 | | ||||||||||||||||||||||
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