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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1decreases expressionEXP 6480464CTDoxaliplatin results in decreased expression of CDK1 mRNAPMID:25729387
Cdk1multiple interactionsEXP 6480464CTD[oxaliplatin co-treated with Topotecan] results in decreased expression of CDK1 mRNAPMID:25729387
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDoxaliplatin results in decreased expression of CDK1 proteinPMID:16024531
Cdk1increases expressionISOCDK1 (Homo sapiens)6480464CTDoxaliplatin results in increased expression of CDK1 protein; oxaliplatin results in increased expression of CDK1 protein modified formPMID:15204521 PMID:19735649
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