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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1affects localizationISOCDK1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the localization of CDK1 proteinPMID:15837074
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CDK1; Benzo(a)pyrene results in decreased expression of CDK1 mRNAPMID:15837074 PMID:20064835 PMID:21802500 PMID:31555880
Cdk1decreases expressionISOCdk1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CDK1 mRNAPMID:19770486 PMID:22228805
Cdk1increases expressionISOCDK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CDK1 protein modified formPMID:20850422
Cdk1increases expressionISOCdk1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CDK1 mRNAPMID:32417428 PMID:35678645
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