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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1multiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [sodium arsenite results in decreased expression of CDK1 protein]PMID:21964460
Cdk1affects expressionISOCDK1 (Homo sapiens)6480464CTDsodium arsenite affects the expression of CDK1 mRNAPMID:29301061
Cdk1affects phosphorylationISOCDK1 (Homo sapiens)6480464CTDsodium arsenite affects the phosphorylation of CDK1 proteinPMID:18501396
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of CDK1 mRNA; sodium arsenite results in decreased expression of CDK1 proteinPMID:30528433 PMID:32844245
Cdk1decreases expressionISOCdk1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of CDK1 mRNA; sodium arsenite results in decreased expression of CDK1 protein; sodium arsenite results in decreased expression of CDK1 protein modified formPMID:16014739 PMID:16338954 PMID:30278210
Cdk1increases expressionISOCDK1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of CDK1 mRNAPMID:12016162
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of and results in decreased phosphorylation of CDK1 protein; sodium arsenite results in increased expression of and results in increased phosphorylation of CDK1 protein; TP53 protein inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of CDK1 protein]PMID:16614167 PMID:28586017
Cdk1multiple interactionsISOCdk1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of and results in increased phosphorylation of CDK1 proteinPMID:30278210
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