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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2307
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd44
Name: CD44 molecule
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd44increases expressionEXP 6480464CTDCisplatin results in increased expression of CD44 mRNAPMID:18289764
Cd44affects expressionISOCD44 (Homo sapiens)6480464CTDCisplatin affects the expression of CD44 mRNAPMID:23300844
Cd44decreases response to substanceISOCD44 (Homo sapiens)6480464CTDCD44 gene mutant form results in decreased susceptibility to Cisplatin; CD44 protein results in decreased susceptibility to CisplatinPMID:21124918 PMID:21471434
Cd44increases expressionISOCd44 (Mus musculus)6480464CTDCisplatin results in increased expression of CD44 mRNAPMID:21151649
Cd44increases expressionISOCD44 (Homo sapiens)6480464CTDCisplatin results in increased expression of CD44 mRNA; Cisplatin results in increased expression of CD44 proteinPMID:21618587 PMID:27392435
Cd44multiple interactionsISOCD44 (Homo sapiens)6480464CTD[NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of CD44 proteinPMID:30291867
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