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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cbr1
Name: carbonyl reductase 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr1multiple interactionsISOCBR1 (Homo sapiens)6480464CTD[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein]PMID:25541467
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