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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cbr1
Name: carbonyl reductase 1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr1increases expressionISOCBR1 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of CBR1 mRNA; Oxygen deficiency results in increased expression of CBR1 proteinPMID:24975222
Cbr1multiple interactionsISOCBR1 (Homo sapiens)6480464CTD3,5-dihydroxy-4'-methoxystilbene inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 protein]; HIF1A mutant form inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 mRNA]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of CBR1 protein]PMID:24975222
Cbr1multiple interactionsISOCbr1 (Mus musculus)6480464CTD[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CBR1 mRNAPMID:30529165
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