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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2280
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cav1
Name: caveolin 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cav1affects expressionISOCAV1 (Homo sapiens)6480464CTDValproic Acid affects the expression of CAV1 mRNAPMID:25979313
Cav1decreases expressionISOCAV1 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of CAV1 mRNAPMID:29154799 PMID:29501571
Cav1decreases methylationISOCAV1 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of CAV1 genePMID:29154799
Cav1increases expressionISOCAV1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of CAV1 mRNA; Valproic Acid results in increased expression of CAV1 proteinPMID:23179753 PMID:24383497 PMID:24935251 PMID:26238599 PMID:26272509 PMID:28001369 PMID:29501571
Cav1increases methylationISOCAV1 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of CAV1 genePMID:29501571
Cav1multiple interactionsISOCAV1 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAV1 mRNAPMID:27188386
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