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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2280
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cav1
Name: caveolin 1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cav1decreases expressionISOCAV1 (Homo sapiens)6480464CTDarsenite results in decreased expression of CAV1 mRNAPMID:31646340
Cav1increases phosphorylationISOCav1 (Mus musculus)6480464CTDarsenite results in increased phosphorylation of CAV1 proteinPMID:14511371
Cav1multiple interactionsISOCav1 (Mus musculus)6480464CTDtyrphostin 25 inhibits the reaction [arsenite results in increased phosphorylation of CAV1 protein]PMID:14511371
Cav1multiple interactionsISOCAV1 (Homo sapiens)6480464CTDarsenite inhibits the reaction [Fulvestrant results in decreased expression of CAV1 mRNA]; arsenite promotes the reaction [G3BP1 protein binds to CAV1 protein]; CAV1 protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK1 protein]; CAV1 protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [arsenite results in decreased expression of CAV1 mRNA]PMID:12640124 PMID:31646340 PMID:32406909
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