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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2280
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cav1
Name: caveolin 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cav1decreases expressionEXP 6480464CTDresveratrol results in decreased expression of CAV1 proteinPMID:18266981
Cav1multiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [Streptozocin promotes the reaction [CAV1 protein binds to NOS3 protein]]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of CAV1 protein]PMID:18266981
Cav1affects transportISOCAV1 (Homo sapiens)6480464CTDCAV1 protein affects the transport of resveratrolPMID:19321006
Cav1increases expressionISOCAV1 (Homo sapiens)6480464CTDresveratrol results in increased expression of CAV1 proteinPMID:19321006
Cav1increases phosphorylationISOCAV1 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of CAV1 proteinPMID:18296501
Cav1increases response to substanceISOCAV1 (Homo sapiens)6480464CTDCAV1 protein results in increased susceptibility to resveratrolPMID:19321006
Cav1multiple interactionsISOCAV1 (Homo sapiens)6480464CTD[Coumestrol co-treated with resveratrol] results in increased expression of CAV1 mRNA; [resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]] which results in increased abundance of Nitric Oxide; resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]PMID:18296501 PMID:19167446
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