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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279 Species: Rattus norvegicus RGD Object: Gene Symbol: Cat Name: catalase

Acc ID: CHEBI:64317 Term: isoprenaline Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. CasRN: 7683-59-2 Chemical ID: MESH:D007545

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:737448	6480464	CTD	Isoproterenol results in decreased expression of CAT protein	PMID:12708743
increases expression	ISO	RGD:737448	6480464	CTD	Isoproterenol results in increased expression of CAT mRNA	PMID:20003209
multiple interactions	EXP		6480464	CTD	Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]	PMID:15740881
multiple interactions	EXP		6480464	CTD	dicarbine inhibits the reaction [Isoproterenol promotes the reaction CAT] dicarbine inhibits the reaction [Isoproterenol results in increased activity of CAT protein]	PMID:1840475
multiple interactions	EXP		6480464	CTD	Gallic Acid inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]	PMID:19146839
increases reaction	EXP		6480464	CTD	Isoproterenol promotes the reaction CAT	PMID:1840475
decreases activity	EXP		6480464	CTD	Isoproterenol results in decreased activity of CAT protein	PMID:15740881 PMID:16584858 PMID:16697266
decreases expression	EXP		6480464	CTD	Isoproterenol results in decreased expression of CAT protein	PMID:19146839
multiple interactions	EXP		6480464	CTD	mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]	PMID:16697266 PMID:16584858
decreases activity	EXP		6480464	CTD	Isoproterenol results in decreased activity of CAT protein	PMID:16584858 PMID:15740881 PMID:16697266
increases activity	EXP		6480464	CTD	Isoproterenol results in increased activity of CAT protein	PMID:1840475
decreases activity	EXP		6480464	CTD	Isoproterenol results in decreased activity of CAT protein	PMID:16697266 PMID:16584858 PMID:15740881
multiple interactions	EXP		6480464	CTD	mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]	PMID:16584858 PMID:16697266
multiple interactions	EXP		6480464	CTD	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]	PMID:21322096
decreases activity	EXP		6480464	CTD	Isoproterenol results in decreased activity of CAT protein	PMID:15740881 PMID:16584858 PMID:16697266 PMID:21322096